Measurement of Serum Procalcitonin in Apollo Lab Medicine Department has initiated a unique approach in diagnosis and management of sepsis. As increased procalcitonin levels can be observed after 3-6 hours in response to sepsis, it works as an early diagnostic marker for systemic bacterial infection. This blood test can also be used to monitor the course and prognosis of life-threatening systemic bacterial infections, as in lower respiratory tract infection (LRTI) and community acquired pneumonia (CAP), to tailor therapeutic interventions more efficiently as in patients with ventilator associated pneumonia (VAP) and to evaluate mortality risk for patients in ICU. Moreover, initiation and duration of antibiotic therapy can be guided by the measurement of procalcitonin levels and its changes over the course of antibiotic treatment. Procalcitonin measurement is helpful after surgical removal of septic focus and/or after start of antibiotic therapy, and also during infectious disease monitoring of high-risk patients, as in after extended surgery or polytrauma.